Дата публикации: 2017-10-12 09:48
Justin D Pearlman, MD, ME, PhD, FACC, MA Chief, Division of Cardiology, Director of Cardiology Consultative Service, Director of Cardiology Clinic Service, Director of Cardiology Non-Invasive Laboratory, Director of Cardiology Quality Program KMC, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School
An electronic copy of this medication guide can be obtained from /Medguide/ or by calling 6-855-778-7898 for alternate delivery options.
Drugs are listed with up to 7 common brand names. There are many more brand names for some of the common drugs, such as pseudoephedrine and erythromycin. It is also important to look at the list of active drugs in medicines that contain a combination of drugs such as Zyrtec-D® , which contains pseudoephedrine. This means that you must look up each ingredient of the drug to see if it is on this list.
The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the . general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 7 to 9% and 65 to 75%, respectively.
We conducted a search of the product information of each SSRI and SNRI regarding QT interval prolongation, searching the primary literature using the MeSH terms “serotonin reuptake inhibitors” and “antidepressive agents.” Another source was The Arizona Center for Education and Research on website termed CredibleMeds, which lists drugs that have a risk of QT prolongation and cardiac arrhythmias. 67 We evaluated these resources collectively to formulate a clinically beneficial overview of SSRI and SNRI agents, their associated effects on QTc prolongation, and their likelihood of causing TdP.
Embryo-Fetal Toxicity : Inform female patients of reproductive potential that Methadone hydrochloride tablets can cause fetal harm and to inform their healthcare provider of a known or suspected pregnancy [see Use in Specific Populations ( )].
Of the SSRIs, citalopram is most commonly associated with QT prolongation. Citalopram is listed on CredibleMeds as a drug with known TdP risk, and the site lists over 655 studies supporting this classification. Among these studies was a systematic review of 68 case reports of citalopram resulting in QTc prolongation, 65 of which were associated with the development of TdP. 68
8758 The Methadone in Methadone hydrochloride tablets may cause spasm of the sphincter of Oddi. Opioids may cause increases in the serum amylase. Monitor patients with biliary tract disease, including acute pancreatitis, for worsening symptoms.
Adrenal Insufficiency: Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use.
All patients treated with opioids for pain management require careful monitoring for signs of abuse and addiction, since use of opioid analgesic products carries the risk of addiction even under appropriate medical use.